With these three books the authors justify a new field in medicine and dentistry:
An interdisciplinary maxillo-mandibular osteoimmunology. All three volumes document the fatty degenerative osteolysis of the jawbone on a case-by-case basis, emphasize their conspicuous overexpression of the inflammatory messenger RANTES/CCL5 and discuss 39 chronic diseases that may have been triggered by it.
The discussion shows that an extension of volume I and volume II was necessary due to the increasing importance and understanding of „silent inflammation” for the immune system.
The investigation of disturbing „signaling pathways” from the jaw area through insufficient wound healing after a tooth removal, inflammatory stimuli from implants and root fillings and their systemic intricacies, makes these three textbooks a cornerstone of medical progress.
Volume I „Cavity forming osteolyses of the jawbone“ Dr. Dr. (PhD-UCN) Johann LechnerSystematic-integral effects of aseptic osteonecrosis “jaw ostitis” and “NICO” in the jaw – Index In the author`s practice, astonishing improvements in rheumatoid, neuralgiform complaints and other systematic diseases are observed after the cleansing of painfree, radiographically incospicuous and toothless jaw areas (NICO). These are structurally characterized by a fatty degenerative osteonecrosis of the cancellous bone. In order to clarify systemic connections, osteolytic and fatty degenerative cancellous bone was taken from a total of 17 subjects and examined for 27 immune messengers using bead-based multiplex technology. All 17 NICO samples consistently show the highest concentrations of RANTES/CCL5. The scientific literature on the causes and metastatic tendencies of breast cancer assigns RANTES a key role as a signalling agent.
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Volume II „Histology & Immunology of the cavity-forming osteolysis of the jawbone“ Dr. Dr. (PhD-UCN) Johann LechnerOral and systemic manifestation of a Maxillo-Mandibular Osteoimmunology – Index With this book three athors enter a new field in medicine and dentistry: an interdisciplinary Maxillo-Mandibular Osteo-Immunology. They present it case-related and casuistically and discuss the diseases associated with a fatty degenerative osteolysis of the jawbone (FDOK). After Volume I with the title „Cavity forming osteolysis of the jawbone” published in 2011, further scientific data on FDOK is now available. Prof. Bouquot has made his extensive histological imagery on FDOK “NICO” obtainable and 2000 own histologies from FDOK were analyzed and evaluated in addition.
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Volume III „Cavity forming osteolysis of the jawbone“ Dr. Dr. (PhD-UCN) Johann LechnerDental pathomechanisms of chronic inflammatory diseases – Index After Volume I from 2011 and Volume II from 2015, Volume III, on the cavity-forming osteolyses of the jawbone with their oral and systemic manis fixations, will be published in 2019. These three books by the authors Dr. Dr. (PhDUCN) J. Lechner, Prof. JE. Bouquot and Dr. V. von Baehr with more than 600 colored illustrations and over 1,000 literature citations on more than 800 pages explain and justify the new therapy and research branch of a „Maxillo-Mandibular Osteoimmunology”.
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